Medical Monitors plays important role throughout the trial. Azelix Medical Monitoring team joins discussion as early as in pre-IND stage to ensure overall drug development strategy meets current needs from patients. Then, our team continues to give I/E criteria and other safety related input to have a well-balanced protocol from regulatory, operational, and patient safety perspectives. When it comes to clinical execution phase, assigned Medical Monitor will make sure to be available 24/7 as needed to provide medical feedback in timely manner.